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Atai Life Sciences (NASDAQ:ATAI) mentioned it dosed the primary particular person in a part 1 trial of VLS-01 for treatment-resistant despair (TRD).
VLS-01 is an artificial type of N,N-dimethyltryptamine (DMT) being developed for TRD, the corporate mentioned in an Oct. 5 press launch.
DMT is a sort of psychedelic.
The trial is placebo-controlled research to guage the relative bioavailability of buccal (mouth/cheek) versus IV formulations, security and tolerability of VLS-01 administered by each routes, and pharmacodynamics of DMT utilizing qEEG and different measures, the corporate famous.
“A sensible strategy to DMT administration would give individuals entry not solely to the pharmacological advantages of DMT however may also afford them time to discover the private insights from their experiences with therapists,” mentioned Glenn Quick, senior vp, early growth of atai.
The corporate famous that buccal VLS-01 is formulated to supply a psychedelic expertise lasting 30 to 45 minutes, thus doubtlessly permitting for a shorter clinic go to in comparison with many different psychedelic compounds that will require a affected person to be monitored for 4 or extra hours.
Atai added that the trial contains the companion use of atai’s IDEA-1 digital therapeutic app to supply contextual “(thoughts)set-and-setting” previous to dosing, and behavioral activation remedy, group remedy, and affected person monitoring post-dosing.
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