It is wonderful how one 12 months can change every thing. On Nov. 19, 2021, the Nasdaq-100 index — which is made up of the 100-largest Nasdaq Composite shares — hit a report closing excessive of 16,573.34. These good points got here because the Federal Reserve saved charges low, boosting the costs buyers had been prepared to pay for the tech sector. The 12 months that is adopted since that milestone hasn’t been practically as form to the Nasdaq-100. The index has dropped roughly 30% in that point, tumbling deep right into a bear market. These losses have been pushed by a mixture of things, together with buyers dumping Covid-19 winners because the world continued to reopen from the pandemic, and corporations with excessive valuations or no-to-low low earnings falling out of favor in a rising-rate setting. DocuSign and Zoom Video have fallen greater than 80% and 67%, respectively, for the reason that Nasdaq-100 reached its report excessive. Each shares soared on the onset of the Covid-19 pandemic in 2020, as working remotely from dwelling took maintain. However, buyers dumped the shares as international locations reopened and staff returned to the workplace. Staff collaboration software program identify Atlassian is one other beaten-down pandemic darling that has misplaced about 71% over the previous 12 months. Megacap shares resembling Meta Platforms , Tesla and Amazon have additionally plunged over the previous 12 months, partly attributable to their excessive valuations. Traders have largely shunned such costly shares because the Federal Reserve tightened financial coverage to curb inflationary pressures not seen in many years. Meta, the Fb and Instagram father or mother, has misplaced greater than 67% for the reason that report was reached, whereas Tesla and Amazon have fallen round 50% every. To make certain, there are a couple of Nasdaq-100 names which have thrived regardless of the index’s tumble, together with Vertex Prescribed drugs or Amgen . Vertex Prescribed drugs has rallied 69.5% for the reason that Nasdaq-100 closed at a report. Earlier this month, the corporate reported better-than-expected quarterly outcomes and hiked its full-year outlook. “As we progress exa-cel in the direction of international regulatory submission, provoke pivotal improvement of the acute ache program and proceed the fast development of a number of mid- and late-stage medical packages, we’re executing on our purpose of serial innovation for sufferers, which can drive vital progress for the corporate for years to return,” CEO Reshma Kewalramani mentioned in a press release. Exa-cel is a remedy for sickle cell illness. In the meantime, Amgen has surged 39.4% in that point, with Goldman Sachs analyst Salveen Richter noting earlier this month that the corporate’s weight problems drug supplies a “blockbuster alternative” for buyers. O’Reilly Automotive, T-Cell and Gilead Sciences are additionally among the many huge Nasdaq-100 winners over the 12 months for the reason that Nasdaq closed at an all-time excessive. Shares of O’Reilly and T-Cell are up roughly 30% every in that point, whereas Gilead has gained 21.7%. — CNBC’s Michael Bloom contributed reporting.